Abstract: The cancer Biomedical Informatics Grid, or caBIG(TM), is a voluntary virtual informatics infrastructure that connects data, research tools, scientists, and organizations to leverage their combined strengths and expertise in an open federated environment with widely accepted standards and shared tools. The underlying service oriented infrastructure that supports caBIG(TM) is referred to as caGrid. Driven primarily by scientific use cases from the cancer research community caGrid provides the core enabling infrastructure necessary to compose the Grid of caBIG(TM). It provides the technology that enables collaborating institutions to share information and analytical resources efficiently and securely, and allows investigators to easily contribute to and leverage the resources of a national-scale, multi-institutional environment. The caBIG initiative is a four-year project, funded by the National Cancer Institute, with the mission of linking the more than 60 cancer centers across the U.S. into an integrated distributed-computing system. In this talk I will go over description of the caBIG program, and how the concepts of service oriented science are used in achieving the objective the caBIG program (finding a cure for cancer !)