Cancer Drug Discovery: Targeting PI3K/AKT/mTOR Cell Survival Pathway

Event Sponsor: 
Computing, Environment and Life Sciences Seminar
Start Date: 
Jul 18 2018 - 1:00pm
Building 240/Room 4301
Argonne National Laboratory
Rengul Cetin-Atalay
Speaker(s) Title: 
Cancer Systems Biology Laboratory, Graduate School of Informatics, ODTU, Ankara Turkey
Gordon Pusch

Dr. Cetin-Atalay’s group has been working on the discovery of novel anticancer candidate molecules for epithelial cancers focusing on liver cancer. Her talk will focus on the importance of PI3K/AKT/mTOR network for targeted cancer drug discovery . She will present two sets of molecules inducing oxidative stress and alter PI3K/AKT/mTOR network as well as other kinase inhibitors for therapeutic strategies in Liver cancer stem cells. Finally, a novel method in the field of computational drug discovery and its experimental validation on the PI3K/AKT signaling pathway in liver cancer cells.